Larotrectinib Impurity 7

Larotrectinib Impurity 7 - Names and Identifiers

Name	(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE
Synonyms	Larotrectinib Impurity 7 Larotrectinib Pyrrolidine Impurity (R)-2-(2,5-difluorophenyl)pyrrolidine (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE (2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE-HCL Pyrrolidine, 2-(2,5-difluorophenyl)-, (2R)- (R)-2-(2,5-Difluorophenyl)pyrrolidine fandachem (2R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride
CAS	1218935-59-1
EINECS	227-251-0

Larotrectinib Impurity 7 - Physico-chemical Properties

Molecular Formula	C10H11F2N
Molar Mass	183.2
Density	1.164±0.06 g/cm3(Predicted)
Boling Point	213.5±40.0 °C(Predicted)
pKa	9.02±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Use	Uses 2-(2, 5-difluorophenyl) pyrrolidine is used in the synthesis of imidazoles [1,2-b] pyrazines and as Trk kinase inhibitors.

Larotrectinib Impurity 7 - Upstream Downstream Industry

Raw Materials	5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole Pyrrolidine, 2-(2,5-difluorophenyl)-1-[(S)-(1,1-dimethylethyl)sulfinyl]-, (2R)- (R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate
Downstream Products	(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine LOXO-101 (sulfate)

Larotrectinib Impurity 7 - Introduction

(2R)-2-(2,5-difluorophenyl) PYRROLIDINE, also known as (2R)-(2R)-2-(2,5-difluorophenyl) PYRROLIDINE, is an organic compound. It has the chemical formula C11H12F2N and has one chiral center.

(2R)-2-(2,5-difluorophenyl) PYRROLIDINE is mainly used as a pharmaceutical intermediate and has important applications in the synthesis of pharmaceutical compounds. It is widely used in the pharmaceutical field for the synthesis of antipsychotic, especially antischizophrenic, drugs. In addition, it is used as an intermediate for pesticides and insecticides in the agricultural sector.

The preparation of (2R)-2-(2,5-difluorophenyl) PYRROLIDINE can be obtained by the reaction of styrene and fluorine gas. In the reaction, (2R)-2-(2,5-difluorophenyl) PYRROLIDINE is generated by fluorination of styrene with fluorine gas in the presence of a catalyst and an active oxidant.

With regard to safety information, there is currently no report on the specific danger of (2R)-2-(2,5-difluorophenyl) PYRROLIDINE. However, since it is an organic compound, attention should be paid to correct handling and storage methods when using it, and avoid contact with skin, eyes and other sensitive areas. At the same time, the synthesis and handling of the compound should follow the relevant laboratory safety practices to ensure safety and the effectiveness of protective measures.

Last Update：2024-04-09 21:11:58